Building CSS mobile-first is the way forward, because blah blah blah progressive enhancement blah. Problem is, Internet Explorer prior to 9 ignores anything within media query blocks, leaving those browsers with mobile styles.
Not all of us can get away with that, but thankfully, as Chris Eppstein points out, Sass 3.2 (not yet released) can generate a separate stylesheet with everything it needs to create a "desktop" look.
This page was built mobile-first where smaller width devices get a single column layout, but IE8 and below still get a two column layout.
Posted by Henning Koch to makandra dev (2012-06-04 09:33)