Sometimes you need to restart the Gnome panel, e.g. when you installed a new Gnome panel widget but the widget list was cached before.

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You often don't want to do sign out and back in for this.
Instead, just run:

killall gnome-panel

This will terminate all gnome-panel processes. On my machine (Ubuntu 11.04) the panel then restarted itself after a moment.

If the panel does not automatically come back, press Alt+F2 to bring up the Gnome "run" box and start gnome-panel from there.